Clinical Proteomics – Neuroscience
Since I have my background in clinical neuroscience (Med. Dr., Assoc. Professor in Clinical Neuroscience, Sahlgrenska University Hospital, Göteborg University) my focus is to apply advanced analytical chemistry as tools in preclinical as well as clinical studies.
One of the key objectives of modern neuroscience and biomedicine is to find methods both for detection and structural analysis of specific molecules. These molecules can reflect and help us understand the mechanisms of signal transduction between cells both within the central nervous system (CNS), and between the CNS and peripheral systems such as the immune system.
My interest in modern analytical tools applied in biomedical issues such as neuroscience and neuroimmunology have lately triggered me to use modern mass spectrometry (MS) such as matrix assisted laser desorption ionization tandem time of flight mass spectrometry (MALDI-TOF/TOF MS) and high resolution nanoelectrospray MS such as Fourier Transform Ion Cyclotron Resonance (ESI FT-ICR MS), in conjunction with multidimensional capillary electrophoresis (CE), capillary electrochromatography (CEC), micro-liquid chromatography (uLC) and microchip based devices (uTAS). These powerful techniques will dramatically increase the possibility of achieving absolute molecular identification and structural characterization of substances related to important biomedical questions.
High resolution MS, CE-MS and LC-MS has become excellent complements to 2D-gel-electrophoresis MS based strategies in addressing processes concerning e.g. neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and Schizophrenia. The goal is to further understand the molecular pathogenesis of and find early biomarkers for the ongoing neurodegenerative process. The new analytical methods may also become helpful in the investigations of neuroimmunological disorders such as multiple sclerosis and rheumatoid arthritis.
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